Calcium Alpha-Ketoglutarate (Ca-AKG) is a stable, easily absorbed form of alpha-ketoglutarate—a compound naturally found in the body that plays a vital role in metabolism, cellular energy, and overall cellular function.
As we get older, our natural levels of AKG drop dramatically, which has prompted growing interest in supplementing it to help counteract some age-related changes.
AKG is known to support cellular regeneration and helps power essential processes during times of growth, repair, and recovery. It also contributes to protein metabolism and supports both digestive and kidney function.
By the age of 80, our AKG levels may fall to just 10% of what they were at 40, making supplementation a promising strategy for supporting long-term health and vitality.
The calcium-bound version, Ca-AKG, improves absorption and bioavailability—making it a practical and efficient way to access AKG’s potential benefits, which may include reduced frailty and improved overall wellness as we age.
A key 2020 study by Dr. Brian Kennedy and researchers at the Buck Institute for Research on Aging showed promising results for Calcium Alpha-Ketoglutarate (Ca-AKG) in extending health span and lifespan—in mice.
Ca-AKG extended median lifespan in mice by ~12% for females and ~10% for males.
Health span improvements were even more significant: the treated mice remained healthier and more active as they aged.
The compound appeared to reduce levels of systemic inflammation, a major driver of aging.
Mice supplemented with Ca-AKG looked and behaved younger, showing better posture, fur quality, and activity levels.
So, whilst it’s early days in the timeline of clinical studies, if these outcomes are replicated in humans, then we are looking at an extra 7-9 years of healthy life span.
